Ion Channel Genealogy Visualizer

Launch VisualizerBrowse OmnimodelsRead the PaperView on GitHub

What’s Inside

Omnimodels (Standard HH Formulation)

Steady states via sigmoids; τ(V) via a thermodynamic 4th‑order form. We fitted 3,524 channels; most are indistinguishable from originals under ICG protocols. Fit quality is reported for gates and for protocol responses.

Per‑Channel Specification Sheets

For each channel: IDs (ModelDB/ICG), gate set & exponents, x∞(V) and τ(V) at 3 temps, gₘₐₓ (6.3 °C & 37 °C) with Q₁₀ (when present), omnimodel coefficients + errors, clone pool membership and links.

What are omnimodels?

A standard Hodgkin–Huxley parameterization of voltage‑gated channels.

  • x∞(V): sigmoid (optionally scaled/offset)
  • τ(V): flexible 4‑term thermodynamic form

Why it matters: compare channels by parameters, swap mechanisms across neuron models, and infer channel properties from standard protocols.

Accuracy & limits

  • Scope: HH voltage‑gated (K, Na, Ca, Ih, KCa). No Markov/metabotropic here.
  • Temperature handling is heterogeneous across legacy models; in our extractions: 49 % show τ temperature dependence; 12 % show conductance Q₁₀.
  • Some originals use non‑sigmoidal or discontinuous functions; those may show higher deviations (we flag them).
Launch VisualizerBrowse OmnimodelsRead the PaperView on GitHub